Publications by authors named "R Mellone"
Article Synopsis
- Mucopolysaccharidosis type I Hurler (MPSIH) causes severe skeletal issues that aren't fully improved by traditional stem cell transplants (HSCT), but autologous gene therapy (HSPC-GT) shows promise for better metabolic outcomes.
- In a clinical trial with eight young patients (average age 1.9 years), those who underwent HSPC-GT were evaluated over four years for various growth and skeletal measures, showing significant improvements compared to those treated with HSCT.
- After nearly four years, HSPC-GT patients demonstrated better growth, joint mobility, and reduced signs of hip dysplasia, indicating early positive impacts on skeletal health, but more long-term data is needed for con
Article Synopsis
- Non-traumatic acute bilateral compartment syndrome is a rare but serious condition that can cause limb ischemia, highlighted in a case involving a young woman after a five-kilometer walk while taking lurasidone.
- The patient experienced complications like bilateral foot-drop and rhabdomyolysis, but due to her late arrival at the hospital, doctors chose to monitor her condition conservatively instead of immediate surgery.
- Despite the initial severe symptoms, her health improved over time, allowing her to resume daily activities within weeks, although she still had ongoing foot-drop issues likely related to her medication and the stress of mild exercise on her muscles.
Purpose: Spontaneous bleeding is a rare but serious complication of parathyroid adenomas and few cases were reported in the literature. Clinical manifestations and treatment may vary but sometimes an immediate surgery is required. In other cases a conservative approach can be preferred based on clinical stability and patients' conditions.
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