Publications by authors named "R Melamed"
Background: Current effective breast cancer treatment options have severe side effects, highlighting a need for new therapies. Drug repurposing can accelerate improvements to care, as FDA-approved drugs have known safety and pharmacological profiles. Some drugs for other conditions, such as metformin, an antidiabetic, have been tested in clinical trials for repurposing for breast cancer.
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- A study conducted on Israeli neonatal herpes simplex virus (NHSV) infection collected data from 2015 to 2022, comparing clinical characteristics of NHSV patients with those suffering from neonatal enteroviral meningitis (NEM).
- The results showed an NHSV incidence of 5.9 per 100,000 live births, with notable demographics suggesting that horizontal transmission was linked to practices like ritual circumcision.
- NHSV patients presented unique symptoms such as a lower incidence of fever and irritability but showed a tendency for rashes and seizures, marking a distinct clinical profile compared to NEM, which can help guide treatment approaches for infected newborns.
Shared etiology of Mendelian and complex disease supports drug discovery.
BMC Med Genomics
September 2024
Background: Drugs targeting disease causal genes are more likely to succeed for that disease. However, complex disease causal genes are not always clear. In contrast, Mendelian disease causal genes are well-known and druggable.
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- Blastomycosis can severely affect the lungs and is associated with high mortality rates, leading some patients to require veno-venous extracorporeal membrane oxygenation (VV-ECMO) for rescue therapy.
- A recent report tracked eight patients with respiratory failure from blastomycosis who were treated with VV-ECMO between 2019 and 2023, showing promising survival rates with all patients surviving ECMO decannulation and seven discharged from the hospital.
- The study highlights that starting ECMO support early may improve outcomes for these patients, despite some challenges in managing individuals with obesity and noting common post-treatment complications like pulmonary infiltrates.