Measurement of the indoor and outdoor (220)Rn (thoron) equilibrium factor: application to lung dose.

A miniature four-chamber alpha track detector was developed that measures both (222)Rn (radon) and (220)Rn (thoron), in duplicate. Using this detector and the previous long-term measurements of the (220)Rn decay products (212)Pb, and (212)Bi, an equilibrium factor, F(eq), is derived for both outdoor and indoor (220)Rn environments (0.004±0.

Activity of Parthenolide at 5HT2A receptors.

Parthenolide displaces [3H]ketanserin from 5HT2A receptors from rat and rabbit brain and cloned 5HT2A receptors. Ki's are in the 100-250 microM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT2A receptor affinity.

Inhibitory effect of dioctyl sodium sulfosuccinate on trypsin activity.

The inhibitory effect of dioctyl sodium sulfosuccinate on the proteolytic activity of trypsin was investigate over the pH 6-8 range. The antitryptic activity was determined using two different substrates: casein and N,alpha-benzoyl-DL-arginine-p-nitroanilide hydrochloride. The mechanistic studies revealed the substrate-inhibitor interaction to be the overall major mechanism of inhibition.