Publications by authors named "R McQuade"
Global average life expectancy has steadily increased over the last several decades and is projected to reach ~ 77 years by 2050. As it stands, the number of people > 60 years currently outnumbers children younger than 5 years, and by 2050, it is anticipated that the global population of people aged > 60 years will double, surpassing 2.1 billion.
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- The study aimed to evaluate the efficacy, safety, and tolerability of brexpiprazole for treating borderline personality disorder (BPD), as no approved drugs exist for this condition.* -
- In a randomized, double-blind trial, 324 adult patients with BPD were given either brexpiprazole or a placebo for 11 weeks, but the results showed no significant difference between the two groups on the primary outcome measure.* -
- While brexpiprazole did not meet the primary study goal, some positive signals for efficacy were noted at different time points, indicating that further research is needed, especially considering safety concerns like akathisia (restlessness) reported more frequently in brexpipraz
Bacterial cancer therapy (BCT) is a promising therapeutic for solid tumours. Salmonella enterica Typhimurium (STm) is well-studied amongst bacterial vectors due to advantages in genetic modification and metabolic adaptation. A longstanding paradox is the redundancy of T cells for treatment efficacy; instead, STm BCT depends on innate phagocytes for tumour control.
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- Legumain is an enzyme linked to inflammation and has been found to activate a receptor that causes pain in oral cancer, but its role in the gastrointestinal tract, particularly in colon health, is less understood.
- In studies using a specialized probe, researchers found that legumain is activated in specific colon cells during acute colitis, but inhibiting or removing legumain did not affect colon cell permeability or colitis symptoms in mouse models.
- Advanced proteomic analyses revealed potential interactions and substrates of legumain, suggesting possible functions in the gut and its contribution to the development of colorectal cancer amidst inflammation.
The enteric nervous system (ENS) consists of an extensive network of neurons and glial cells embedded within the wall of the gastrointestinal (GI) tract. Alterations in neuronal distribution and function are strongly associated with GI dysfunction. Current methods for assessing neuronal distribution suffer from undersampling, partly due to challenges associated with imaging and analyzing large tissue areas, and operator bias due to manual analysis.
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