Publications by authors named "R McKinnon"
Background: Tumour mutational burden (TMB) is an established biomarker for patients treated with immune checkpoint inhibitors (ICIs). The optimal TMB cut-off is uncertain. It is also uncertain whether there is a sharp TMB threshold or a more graduated change in clinical outcomes as TMB increases.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined the individual participant data-sharing eligibility of clinical trials for the top 30 highest-revenue drugs approved by the FDA in 2021, finding that 64% of the 316 trials were eligible for sharing.
- - Methods involved analyzing data from various sources and assessing key factors like trial phase and completion dates to determine the trials' data-sharing status.
- - Results indicated higher eligibility rates for trials managed through independent data-sharing platforms and emphasized that trials not marked as completed had notably lower eligibility for data sharing.
Purpose: The language that school professionals use to describe disabled students can reveal and perpetuate ableist assumptions. Professionals' language choices can also challenge ableist attitudes to help create more inclusive, equitable learning environments. This tutorial seeks to guide speech-language pathologists (SLPs) and other school professionals to identify ableist language, understand the ableist ideologies that such language reveals, and develop strategies to implement ways of communicating with and about disabled students that align with an anti-ableist stance.
View Article and Find Full Text PDFParents are expected to exhibit intermediate levels of investment in parental care that reflect the trade-off between current versus future reproduction. Providing parents with supplemental food may allow for increased care to the current brood (additive model), re-allocation of parental effort to other behaviours such as self-maintenance (substitution model), or may provide parents with a buffer against provisioning shortfalls (insurance model). We investigated the impact of parental food supplementation on provisioning behaviour and breeding success in Arctic-breeding peregrine falcons () over five successive breeding seasons (2013-2017).
View Article and Find Full Text PDFBackground: Patients with multiple myeloma (MM) are at risk of venous thromboembolism (VTE), worsened by immunomodulatory drugs. Although antithrombotics are recommended for prophylaxis, existing guidelines are suboptimal and treatment outcomes remain unclear.
Objectives: This study aimed to investigate adverse events, antithrombotic utilization, and their associations with survival outcomes in patients with MM initiating multi-drug immunomodulatory combinations.