Publications by authors named "R McGinn"
Background And Objectives: Deep brain stimulation (DBS) targeting the anterior nucleus of the thalamus (ANT) has been shown to be effective in treating some patients with medically refractory epilepsy. However, it remains unknown how seizures spread through the ANT relative to other thalamic nuclei. This study aimed to investigate, through simultaneous recordings from both ANT and pulvinar (PLV) nucleus, their roles in seizure propagation.
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- - The study investigates how intraoperative hypotension (low blood pressure during surgery) affects kidney function after transplantation, focusing on duration and levels of mean arterial pressure (MAP).
- - Analyzing 1,602 kidney transplants over a decade, researchers found that hypotension (specifically, MAP below 65 mmHg for >5 minutes) is linked to a significant risk of delayed graft function (DGF), where kidney function does not improve promptly post-surgery.
- - While DGF occurred in 33% of patients analyzed, the research suggests that lower MAP levels (especially <55 mmHg) contribute to poorer early kidney function outcomes, but the need for dialysis shortly after transplantation was not tied to intraoperative hypot
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- Intraoperative dialysis during liver transplant surgeries is debated, especially for patients with certain kidney and lung issues, as it helps reduce stress on the heart.
- A 54-year-old woman who had serious liver problems, needing both a new liver and dialysis, underwent a liver transplant while using two dialysis catheters to manage her condition.
- The doctors removed excess fluid during the surgery, which helped her heart not get overloaded and allowed for a successful liver transplant.
Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy. However, a substantial proportion continues to suffer from seizures even after surgery. We identified the fasciola cinereum (FC) neurons of the posterior hippocampal tail as an important seizure node in both mice and humans with epilepsy.
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- Metastasis is the leading cause of death in breast cancer, necessitating an understanding of tumor cell migration and its correlation between in vitro and in vivo behavior.
- In a study using immunocompromised mice, six human triple-negative breast cancer (TNBC) cell lines were evaluated for their tumor growth, metastasis, and characteristics such as morphology, proliferation, and motility.
- The findings categorized cell lines by their metastatic potential and showed that morphological metrics were the best predictors of tumor growth and metastasis, while in vitro motility assays did not significantly correlate with in vivo outcomes.