Unusual Water-Soluble Imino Phosphine Ligand: Enamine and Imine Derivatives of 1,3,5-Triaza-7-phosphaadamantane (PTA).

A series of water-soluble and air-stable E-enamine derivatives of 1,3,5-triaza-7-phosphaadamantane (PTA), PTA═C(R)NH, 1-4, are reported along with data on E-Z isomerization and tautomerization to the imine form (PTA-CR═NH). Reaction of 1,3,5-triaza-7-phosphaamantane-6-yl lithium, PTA-Li, with aromatic nitriles afforded E-enamine derivatives of PTA in good yield (49-91%). Phosphines 1-4 are stable toward water and air, and do not appear to isomerize or tautomerize, unless coordinated to a metal or oxidized.

[Factors associated with the failure of Intermittent Preventive Treatment for malaria among pregnant women in Yaounde].

Introduction: Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for malaria prevention during pregnancy. We investigated factors associated with the failure of this strategy.

Methods: We conducted a case-control study in two health care facilities in Yaounde, from 1 May 2014 to 30 April 2015.

Hemilabile β-aminophosphine ligands derived from 1,3,5-triaza-7-phosphaadamantane: application in aqueous ruthenium catalyzed nitrile hydration.

A series of β-aminophosphines derived from 1,3,5-triaza-7-phosphaadamantane (PTA) are described. PTA-CHPhNHPh (1), PTA-CH(p-C(6)H(4)OCH(3))NHPh (2), and PTA-CPh(2)NHPh (3) were prepared in good yield (62-77%) by reaction of lithiated PTA with the corresponding imine followed by hydrolysis. Compounds 1 and 2 were synthesized as pairs of diastereomers which were separated by successive recrystallization from THF/hexane.