Publications by authors named "R Mayordomo"
Article Synopsis
- Onychomycosis is a prevalent fungal infection affecting nails, primarily caused by dermatophytes, and it represents about 50% of nail diseases.
- Tea tree essential oil (EO), particularly due to its component terpinen-4-ol, shows promise as a natural antifungal alternative to conventional treatments.
- A study evaluating the effectiveness of various commercial tea tree EOs demonstrated significant antifungal activity, especially against certain dermatophytes, but further clinical research is necessary to establish its long-term effectiveness and safety.
Background: There are evidence indicating that some metabolites of arachidonic acid produced by cytochromes P450 (CYP) and epoxide hydroxylase (EPHX2), such as hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) or dihydroxyeicosatrienoic acids (DHETEs), play an important role in blood pressure regulation and they could contribute to the development of hypertension (HT) and kidney damage. Therefore, the main aim of the study was to evaluate whether the genetic polymorphisms of CYP2C8, CYP2C9, CYP2J2, CYP4F2, CYP4F11 and EPHX2, responsible for the formation of HETEs, EETs and DHETEs, are related to the progression of impaired renal function in a group of patients with hypertension.
Methods: 151HT patients from a hospital nephrology service were included in the study.
Human papillomavirus is the ethological agent of various tumors, including plantar warts as one of the most frequent clinical presentations. Diagnosis of these warts continues to be mainly clinical, and a significant incidence of misdiagnosis leads to inadequate treatment. The aim of this study is to implement and validate a multiplex PCR detection method in the clinical setting to detect HPV in samples and to study genotype distribution in Spain to improve future molecular diagnostics.
View Article and Find Full Text PDFComparative Analysis of Type I Keratin Expression By Nail Consistency: An Immunohistochemistry Study.
Appl Immunohistochem Mol Morphol
April 2022
Article Synopsis
- The nail plate is a key structure in the nail apparatus, highly keratinized and challenging for experimental study.
- Different types of nail consistency were identified through pressure tests on the nail plate.
- Analysis revealed that hard consistency nails have a higher presence of keratin 17 than soft consistency nails, which could aid in diagnosing nail disorders and systemic diseases.
Onychomycosis and human papillomavirus (HPV) plantar warts are common in clinical practice. Clinical diagnosis is based on searching for pathognomonic signs and symptoms. However, due to misdiagnosis, podiatrists may unnecessarily prescribe antifungal treatments or burn lesions with chemical agents.
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