Publications by authors named "R Mathiasen"
: Paediatric PET/CT imaging is crucial in oncology but poses significant radiation risks due to children's higher radiosensitivity and longer post-exposure life expectancy. This study aims to minimize radiation exposure by generating synthetic CT (sCT) images from emission PET data, eliminating the need for attenuation correction (AC) CT scans in paediatric patients. : We utilized a cohort of 128 paediatric patients, resulting in 195 paired PET and CT images.
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- Diffuse midline glioma (DMG) is a highly aggressive brain cancer in children and young adults, with a poor prognosis of less than 10% survival rate after two years; radiotherapy is a key treatment but only offers short-term benefits.
- The REMIT protocol aims to assess the safety and palliative effectiveness of reirradiation for DMG patients, while monitoring various health indicators, including performance status and quality of life.
- The study will also address patient selection bias and standardization issues, with plans to begin patient inclusion in 2024.
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- The cerebrospinal fluid (CSF) holds potential for discovering biomarkers in pediatric brain cancers, but variations in protein levels and age-related differences complicate research.
- The study improved proteome analysis techniques to maximize protein extraction from limited CSF samples, allowing for more detailed insights.
- An optimized workflow enabled the quantification of 2989 unique proteins from just 400 μL of CSF, significantly enhancing the amount of data obtainable from small sample sizes compared to traditional methods.
Objectives: Childhood cancer often presents with non-specific signs and symptoms that might mimic non-malignant disorders including musculoskeletal diseases, potentially leading to rheumatic and orthopaedic misdiagnoses. We aimed to compare clinical presentation, diagnostic interval and survival in paediatric acute myeloid leukaemia (AML) with and without initial musculoskeletal symptoms.
Methods: This nationwide retrospective, cohort study reviewed medical records of 144 children below 15 years diagnosed with AML in Denmark from 1996 to 2018.
Background: Childhood tumors in the central nervous system (CNS) have longer diagnostic delays than other pediatric tumors. Vague presenting symptoms pose a challenge in the diagnostic process; it has been indicated that patients and parents may be hesitant to seek help, and health care professionals (HCPs) may lack awareness and knowledge about clinical presentation. To raise awareness among HCPs, the Danish CNS tumor awareness initiative hjernetegn.
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