Publications by authors named "R Mastrocola"
Advanced glycation end products (AGEs) exert a key pathogenic role in the development of obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the microalga (spirulina, SP) is proposed as a nutritional supplement. Here, we investigated the potential anti-glycating properties of SP enriched with zinc (Zn-SP) and the following impact on diet-induced metabolic derangements.
View Article and Find Full Text PDFIntroduction: Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical disability, frailty and sarcopenia. Total fat mass frequently increases during aging, often coexisting with sarcopenia, thus resulting in an emerging condition defined sarcopenic obesity (SO). Our previous data demonstrated the relevant role of the bromo and extra-terminal domain (BET) proteins inhibitor JQ1 in attenuating inflammation and fibrosis in sarcopenic mice.
View Article and Find Full Text PDFArticle Synopsis
- Diets high in fat and sugars, specifically fructose and galactose, can cause chronic low-grade inflammation and metabolic issues, as shown in a study with male rats.
- The study evaluated various diets over eight weeks, revealing that while body weight and blood glucose levels remained stable, high fat combined with these sugars significantly increased harmful blood lipid levels and liver accumulation of fats.
- Supplementing the diet with fructooligosaccharides (FOS), a type of dietary fiber, was found to mitigate these negative effects by preventing lipid and advanced glycation end-products buildup.