Publications by authors named "R Mastrantonio"

The central nervous system (CNS) is wired by a complex network of integrated glial and neuronal signals, which is critical for its development and homeostasis. In this context, glia-glia communication is a complex and dynamic process that is essential for ensuring optimal CNS function. Semaphorins, which include secreted and transmembrane molecules, and their receptors, mainly found in the plexin and neuropilin families, are expressed in a wide range of cell types, including glia.

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Article Synopsis
  • Semaphorin-plexin signaling, particularly through Semaphorin 4D (SEMA4D) and its receptor Plexin-B1 (PLXNB1), plays a critical role in regulating the tumor microenvironment (TME) and is linked to cancer progression, specifically in triple-negative breast carcinoma.
  • In experiments with PLXNB1-deficient mice, researchers observed a significant reduction in tumor growth and metastasis, increased survival rates, and changes in immune cell behavior, leading to a more effective anti-tumor immune response.
  • Targeting PLXNB1 not only reprogrammed the TME to enhance the efficacy of immunotherapy (specifically anti-PD-1 treatment) but also positions PLX
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Background: The introduction of the vaccine against SARS-CoV-2 has represented a cornerstone in the containment of the pandemic. Our aim was to assess the vaccination schedules in relation to the infection free interval and to the duration of positivity in case of infection.

Study Design: This study involves the SARS-CoV-2 infected people managed by the Local Health Authority ASL 1 Abruzzo.

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Introduction: Construction workers are often exposed to significant injury risk. The aim of our study is to assess their occupational hazards and injury risk perception.

Methods: We administered 256 questionnaires to construction workers.

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Background: The COVID-19 pandemic has ravaged many countries worldwide since December 2019. The high infection rates, and the need for health care assistance for individuals with comorbidities, strained the national health care systems around the world. Outbreak peaks increased the burden on hospitals that where perceived as high-risk places by people, who often decided to cancel or defer hospital visits.

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