The mutational landscape of Staphylococcus aureus during colonisation.

Staphylococcus aureus is an important human pathogen and a commensal of the human nose and skin. Survival and persistence during colonisation are likely major drivers of S. aureus evolution.

Adapting single-walled carbon nanotube-based thin-film transistors to flexible substrates with electrolyte-gated configurations using a versatile tri-layer polymer dielectric.

Flexibility has been a key selling point in the development of carbon-based electronics and sensors with the promise of further development into wearable devices. Semiconducting single-walled carbon nanotubes (SWNTs) lend themselves well to applications requiring flexibility while achieving high-performance. Our previous work has demonstrated a tri-layer polymer dielectric composed of poly(lactic acid) (PLA), poly(vinyl alcohol) with cellulose nanocrystals (PVAc), and toluene diisocyanate-terminated poly(caprolactone) (TPCL), yielding an environmentally benign and solution-processable n-type thin-film transistor (TFT).

Sexual wellness clinic collaborative initiative with a large urban emergency department: sexual health outcomes and linkage to HIV pre-exposure prophylaxis.

Introduction: Despite escalating rates of sexually transmitted infections (STIs) in the United States (US), there has been progressive divestment of sexual health services leading to the reliance on emergency departments (EDs) for sexual healthcare, particularly among vulnerable populations. The Sexual Wellness Clinic (SWC), a novel care delivery model operating in collaboration with the ED, offers comprehensive sexual health services.

Objectives: This study aims to analyze the demographics, STI positivity, and HIV Pre-Exposure Prophylaxis (PrEP) uptake among patients accessing the SWC.

Cardiac remodelling in patients with atrial fibrillation and obstructive sleep apnoea.

Background: Obstructive sleep apnoea (OSA) can cause left atrial (LA) and left ventricular (LV) remodelling, which is linked to atrial fibrillation (AF). Whether continuous positive airway pressure (CPAP) can reverse LA and LV remodelling in patients with OSA and paroxysmal AF (PAF) has yet to be studied. We assessed the impact of CPAP treatment on LA and LV size and function in patients with OSA and PAF before and after catheter ablation.

PBP4 is required for serum-induced cell wall thickening and antibiotic tolerance in .

The bacterial pathogen responds to the host environment by synthesizing a thick peptidoglycan cell wall, which protects the bacterium from membrane-targeting antimicrobials and the immune response. However, the proteins required for this response were previously unknown. Here, we demonstrate by three independent approaches that the penicillin-binding protein PBP4 is crucial for serum-induced cell wall thickening.