Publications by authors named "R Marocco"
Following viral infection, antigen-restricted T lymphocytes are activated and recognize infected cells to eliminate them. A subset of T cells differentiates into memory lymphocytes able to counteract viral rechallenge in a faster and enhanced way. SARS-CoV-2 can escape immune responses leading to a poor clinical outcome.
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- Low-grade endotoxemia, caused by lipopolysaccharide (LPS), is detected in COVID-19 patients, potentially promoting thrombosis through a pro-inflammatory and pro-coagulant state.
- The study measured various biomarkers in 175 COVID-19 patients and 50 healthy controls, finding significantly elevated levels of markers like sNOX2-dp and D-dimer in COVID-19 patients, especially those with acute respiratory distress syndrome (ARDS).
- Results suggest that factors like impaired gut barrier function, high NOX2 activation, and low albumin may lead to low-grade endotoxemia, increasing the risk of thrombotic events in COVID-19 patients.
Article Synopsis
- COVID-19 is associated with abnormal levels of specific cytokines in the body, which may help in managing the disease.
- The study measures various inflammatory cytokines in serum samples from healthy individuals, COVID-19 patients upon hospital admission, and those who have recovered after different timeframes.
- Results showed that IL-10 levels rise during initial infection, while other cytokines like IL-27 and TNF-α fluctuate over time, suggesting that some cytokines may indicate disease severity or the risk of long-term effects after recovery.
Introduction: Skeletal tuberculosis (TB) accounts for about 10 to 35% of extrapulmonary cases and the knee is the most frequent site after the spine and hip. The diagnosis is difficult and largely clinical.
Case Presentation: This is a case of a young Pakistani man with a history of joint pain for about 4 years, who was diagnosed with chronic arthritis of the right knee.
People living with HIV (PLWH) remain at high risk of mortality and morbidity from vaccine-preventable diseases, even though antiretroviral therapy (ART) has restored life expectancy and general well-being. When, which, and how many doses of vaccine should be administered over the lifetime of PLWH are questions that have become clinically relevant. Immune responses to most vaccines are known to be impaired in PLWH.
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