Publications by authors named "R Marchetti"
Recently, human epidermal growth factor receptor 2 (HER2) has emerged as a therapeutic target of interest for non-small-cell lung cancer in humans. The role of HER2 in canine pulmonary adenocarcinomas is poorly documented. To address this gap, this study employed three methodologies: immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS) to investigate the protein expression, gene amplification, and mutation of HER2 in 19 canine primary pulmonary adenocarcinomas.
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- Mycoplasma pneumoniae and Mycoplasma genitalium are bacteria that infect the human respiratory and urogenital tracts by attaching to host cells through cytoadhesins.
- These cytoadhesins bind specifically to sialylated glycans on host surfaces, making them critical for infection.
- Researchers are exploring ways to design inhibitors that block these interactions, which could lead to new treatments for infections caused by these pathogens.
Article Synopsis
- Protein-glycan interactions are essential for various biological processes, including cell recognition and immune response, making their understanding important for both health and disease.
- Computational techniques are crucial for visualizing and analyzing these interactions at the molecular level, particularly using all-atom molecular dynamics simulations.
- This review discusses key computational tools for studying glycans and proteins, detailing their methodologies, applications, and case studies that illustrate their effectiveness in exploring binding kinetics and molecular interactions.
Flavobacterium strains exert a substantial influence on roots and leaves of plants. However, there is still limited understanding of how the specific interactions between Flavobacterium and their plant hosts are and how these bacteria thrive in this competitive environment. A crucial step in understanding Flavobacterium - plant interactions is to unravel the structure of bacterial envelope components and the molecular features that facilitate initial contact with the host environment.
View Article and Find Full Text PDFThe spread of multidrug-resistant strains of , the etiologic agent of gonorrhea, represents a global health emergency. Therefore, the development of a safe and effective vaccine against gonorrhea is urgently needed. In previous studies, murine monoclonal antibody (mAb) 2C7 was raised against gonococcal lipooligosaccharide (LOS).
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