Pharmacogenetics of dabigatran and apixaban in association with gastrointestinal bleeding.

Objectives: To determine whether selected single nucleotide polymorphisms (SNPs) of genes encoding proteins responsible for the activation, transport, or metabolism of dabigatran and apixaban might be associated with a risk of gastrointestinal bleeding in a cohort of adult patients treated with these drugs. No previous study has focused specifically on the association with gastrointestinal bleeding.

Materials And Methods: Ninety-one patients treated with dabigatran or apixaban were genotyped for selected polymorphisms.

Measuring Self-Efficacy to Request Cancer-Related Work Accommodations: Development and Validation of a Brief Survey Instrument.

Objective: Access to work accommodations, such as time off to attend medical appointments, is a key predictor of cancer-related job loss. We aimed to develop and validate a measure of self-efficacy to request and obtain work accommodations related to diagnosis of breast cancer and need for treatment.

Methods: The 5-item Self-efficacy to Ask for Work Accommodations (SAWA) tool was adapted from a scale that measures self-efficacy in patient-physician interactions.

Antithrombin Deficiency: Frequency in Patients with Thrombosis and Thrombophilic Families.

Purpose: Antithrombin (AT) deficiency is a well-known inherited risk factor for venous thromboembolism (VTE). However, F V Leiden and F II20210a mutations have drawn much more attention in the recent years. Therefore, we have decided to analyze the frequency of antithrombin deficiency in different cohorts of patients and tried to formulate indications for its testing.

Comparison of Presentation, Treatment, and Outcomes of Venous Thromboembolism in Long-Term Immobile Patients Based on Age.

Background: Chronic immobility is prevalent, especially as people age. However, little is known about venous thromboembolism (VTE) outcomes in this population.

Objective: To compare the presentation, treatment, and outcomes in chronically immobile (>8 weeks) patients older vs.

[Antithrombotic therapy and digestive endoscopy].

Antithrombotic therapy and digestive endoscopy Antithrombotic therapy comprises anticoagulation and antiplatelet treatment. The number of patients treated with various forms of antithrombotic therapy is growing. Procedures of digestive endoscopy are very frequently indicated by general practitioners and doctors of various specialisations.