Publications by authors named "R Majeti"
Disruption of the epigenetic landscape is of particular interest in acute myeloid leukemia (AML) due to its relatively low mutational burden and frequent occurrence of mutations in epigenetic regulators. Here, we applied an information-theoretic analysis of methylation potential energy landscapes, capturing changes in mean methylation level and methylation entropy, to comprehensively analyze DNA methylation stochasticity in subtypes of AML defined by mutually exclusive genetic mutations. We identified AML subtypes with CEBPA double mutation and those with IDH mutations as distinctly high-entropy subtypes, marked by methylation disruption over a convergent set of genes.
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- Research on genetic mutations in human cancers seeks to understand their role in initiating and maintaining cancer, specifically focusing on acute myeloid leukemia (AML).
- In this study, CRISPR methods were used to correct mutations in AML cells from patients, revealing that while mutations are crucial for starting the disease, they are not needed for its ongoing maintenance.
- These findings suggest that the roles of initiating oncogenes differ significantly from those that sustain cancer, which could influence future cancer treatments and our understanding of cancer progression.
Article Synopsis
- Scientists have learned a lot about blood stem cells, including those involved in leukemia, through different experiments.
- Recently, new technologies have allowed researchers to gather more detailed information about human cells, but they're focusing more on describing things rather than testing how cells actually work.
- The authors believe that better tools for editing genes and studying stem cells will help scientists move from just describing cells to really understanding their functions more effectively.
, the most frequently mutated gene in human cancer, encodes a transcriptional activator that induces myriad downstream target genes. Despite the importance of p53 in tumor suppression, the specific p53 target genes important for tumor suppression remain unclear. Recent studies have identified the p53-inducible gene as a critical effector of tumor suppression, but many questions remain regarding its p53-dependence, activity across contexts, and mechanism of tumor suppression alone and in cooperation with other p53-inducible genes.
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- Myelodysplastic neoplasms/syndromes (MDS) are a diverse set of diseases marked by ineffective blood cell production.
- Recent classification systems by the World Health Organization and the International Consensus have provided more detailed categorizations of MDS based on morphology and genetics.
- A comprehensive and systematic approach is essential for the accurate diagnosis and classification of MDS, as outlined by the International Consortium for MDS (icMDS).