Design, Synthesis, and Antibacterial Activities of Multi-functional C2-Functionalized 1,4-Naphthoquinonyl Organoseleniums.

A practical and efficient reaction for C2-selenylation of 1,4-naphthoquinones has been explored. This coupling reaction of two redox structural motifs, such as 2-bromo-1,4-naphthoquinone with diaryldiselenide / ebselen has been achieved by using sodium borohydride reducing agent at room temperature. Using this approach, several 2-selenylated-1,4-naphthoquinones were obtained in moderate to good yields and thoroughly characterized by multinuclear (1H, 13C, and 77Se) NMR, cyclic voltammetry, and mass spectrometry.

Toward a resource-optimized dynamic quantum algorithm via non-iterative auxiliary subspace corrections.

Recent quantum algorithms pertaining to electronic structure theory primarily focus on the threshold-based dynamic construction of ansatz by selectively including important many-body operators. These methods can be made systematically more accurate by tuning the threshold to include a greater number of operators into the ansatz. However, such improvements come at the cost of rapid proliferation of the circuit depth, especially for highly correlated molecular systems.

3,5-disubstituted pyridines with potent activity against drug-resistant clinical isolates.

We designed and synthesized a series of compounds with a 3,5-disubstituted pyridine moiety and evaluated them against (Mtb) and drug-resistant Mtb clinical isolates. A library of 3,5-disubstituted pyridine was synthesized. The compounds were screened for activity against H37Rv.

Development of naphthalimide hydrazide derivatives as potent antibacterial agents against carbapenem-resistant .

In this work, a novel series of naphthalimide hydrazide derivatives were designed, synthesized and evaluated against a bacterial pathogen panel. Most of the compounds were found to exhibit potent antibacterial activity against carbapenem-resistant BAA 1605, with MIC ranging from 0.5 to 16 μg mL.

Novel Peripherally Selective Cannabinoid Receptor 1 Neutral Antagonist Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice.

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing globally. MASLD is characterized by clinically significant liver steatosis, and a subset of patients progress to more severe metabolic-disorder-associated steatohepatitis (MASH) with liver inflammation and fibrosis. Cannabinoid receptor 1 (CB1) antagonism is a proven therapeutic strategy for the treatment of the phenotypes that underlie MASLD, though work on early centrally penetrant compounds largely ceased following adverse psychiatric indications in humans.