A standardized and automated CBMN assay for biological dosimetry: the CytoRADx™ system.

Major nuclear accidents can result in many casualties, and it is important to assess the absorbed radiation dose to support treatment decisions. Biological dosimetry (BD) allows retrospective determination of dose using biological markers. To achieve consistent cytogenetic assay results across labs, the current practice requires each lab to generate periodic, unique calibration curves using in vitro dose-effect experiments.

CytoRADx: A High-Throughput, Standardized Biodosimetry Diagnostic System Based on the Cytokinesis-Block Micronucleus Assay.

In a large-scale catastrophe, such as a nuclear detonation in a major city, it will be crucial to accurately diagnose large numbers of people to direct scarce medical resources to those in greatest need. Currently no FDA-cleared tests are available to diagnose radiation exposures, which can lead to complex, life-threatening injuries. To address this gap, we have achieved substantial advancements in radiation biodosimetry through refinement and adaptation of the cytokinesis-block micronucleus (CBMN) assay as a high throughput, quantitative diagnostic test.

Development of a High-Throughput and Miniaturized Cytokinesis-Block Micronucleus Assay for Use as a Biological Dosimetry Population Triage Tool.

Biodosimetry is an essential tool for providing timely assessments of radiation exposure. For a large mass-casualty event involving exposure to ionizing radiation, it is of utmost importance to rapidly provide dose information for medical treatment. The well-established cytokinesis-block micronucleus (CBMN) assay is a validated method for biodosimetry.

Scaling behavior of an airplane-boarding model.

An airplane-boarding model, introduced earlier by Frette and Hemmer [Phys. Rev. E 85, 011130 (2012)], is studied with the aim of determining precisely its asymptotic power-law scaling behavior for a large number of passengers N.

Distributed self-regulation of living tissue: beyond the ideal limit.

The present paper is devoted to mathematical description of the vascular network response to local perturbations in the cellular tissue state, being one of the basic mechanisms controlling the inner environment of human body. Keeping in mind individual organs we propose a model for distributed self-regulation of living tissue, which is regarded as an active hierarchical system without any controlling center. This model is based on the self-processing of information about the cellular tissue state and cooperative interaction of blood vessels governing redistribution of blood flow over the vascular network.