Publications by authors named "R Maher"
One-step green synthesis of collagen nanoparticles using Ulva fasciata, network pharmacology and functional enrichment analysis in hepatocellular carcinoma treatment.
Int J Biol Macromol
January 2025
Collagen nanoparticles (collagen-NPs) possess numerous applications owing to their minimal immunogenicity, non-toxic nature, excellent biodegradability and biocompatibility. This study presents a novel sustainable technique for one-step green synthesis of hydrolyzed fish collagen-NPs (HFC-NPs) using a hot-water extract of Ulva fasciata biomass. HFC-NPs were characterized using TEM, FTIR, XRD, ζ-potential analyses, etc.
View Article and Find Full Text PDFPotential Diagnostic Role of Serum Fibroblast Growth Factor-19 in Hepatocellular Carcinoma.
Asian Pac J Cancer Prev
September 2024
Article Synopsis
- A study was conducted to evaluate the potential of Fibroblast Growth Factor-19 (FGF-19) as a new diagnostic biomarker for hepatocellular carcinoma (HCC), aiming to enhance diagnostic accuracy and improve patient survival rates.
- The research included 114 participants divided into three groups (HCC, Cirrhosis, and Control), revealing that FGF-19 levels were significantly different among the groups, with FGF-19 showing 100% sensitivity and specificity for distinguishing HCC from healthy controls.
- The findings suggest that FGF-19 could be a valuable noninvasive serum biomarker for HCC, particularly when used alongside other markers like alpha-fetoprotein (AFP
Article Synopsis
- STING is a key player in sensing cytosolic nucleic acids and regulating type I interferon responses, making it a target for drug discovery due to its role in various diseases.* -
- The study identifies a compound called AK59 that can degrade STING by utilizing the HERC4 E3 ligase, which may allow for targeting proteins traditionally considered "undruggable."* -
- AK59 is effective against common STING mutations, indicating its potential for clinical applications and introducing HERC4 into the conversation around targeted protein degradation.*
Introduction: Moderate-to-high physical activity participation is associated with a reduced risk of infertility. Yet, exercise interventions that target cardiorespiratory fitness, independent of weight loss, are lacking in obesity and female fertility research.
Purpose: The primary objective of the PRO-FIT-CARE (PROmoting FITness for CArdiometabolic & REproductive Health) study was to assess the feasibility of a moderate-to-high-intensity online exercise program for persons with obesity and female infertility.