Publications by authors named "R Mahdian"
Article Synopsis
- Inborne errors of metabolism can lead to neonatal deaths, and this study focused on two unrelated neonates experiencing acute metabolic issues and death.
- Researchers used whole-exome sequencing and other methods to identify genetic variants in the pyruvate carboxylase gene, revealing two variants: one likely pathogenic and another of uncertain significance.
- The findings suggest that these genetic variants are responsible for type B Pyruvate carboxylase deficiency, offering potential for prenatal diagnosis and expanding knowledge of the PC gene for medical professionals.
Non-coding RNAs, including Inc-RNA and miRNA, have been reported to regulate gene expression and are associated with cancer progression. MicroRNA-561-3p (miR-561-3p), as a tumor suppressor, has been reported to play a role in preventing cancer cell progression, and MALAT1 (Lnc-RNA) have also been demonstrated to promote malignancy in various cancers, such as breast cancer (BC). In this study, we aimed to determine the correlation between miR-561-3p and MALAT1 and their roles in breast cancer progression.
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- CHO cells are integral for recombinant biotherapeutic production, yet their low productivity is primarily hindered by apoptosis, prompting research to enhance their performance.* -
- The study utilized CRISPR/Cas9 technology to disrupt the BAX gene, resulting in increased cell viability and higher erythropoietin production rates in manipulated CHO cells, even under stress conditions.* -
- The findings suggest that editing anti-apoptotic genes like BAX can significantly improve CHO cell productivity, indicating a promising avenue for more efficient biomanufacturing processes.*
Background: K-Ras mutations rarely occur in breast cancer. However, studies have supported that K-Ras upregulation is involved in breast cancer pathogenesis. Two main K-Ras transcript variants; K-Ras4A and K-Ras4B, originate from the alternative splicing of exon 4.
View Article and Find Full Text PDFBackground: Chinese hamster ovary (CHO) cells are the widely used mammalian cell host for biopharmaceutical manufacturing. During cell cultures, CHO cells lose viability mainly from apoptosis. Inhibiting cell death is useful because prolonging cell lifespans can direct to more productive cell culture systems for biotechnology requests.
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