Cyclometalated Ir Complex Possessing Chiral MIC ligand: Regiospecific sp C-H Activation and Asymmetric Transfer Hydrogenation of Ketone.

Cyclometalation offers a wide number of organometallic metallacycles showing diverse applications. However, such NHC complexes synthesized via an sp C-H bond activation are rare. An iridium(III) complex with a chiral mesoionic N-heterocyclic carbene (MIC) ligand, where the Ir forms an additional Ir-C bond via a regiospecific sp C-H bond activation at the N-methylbenzyl wingtip, was synthesized and characterized.

A spatial autocorrelation analysis of road traffic accidents by severity using Moran's I spatial statistics: a study from Nepal 2019-2022.

Background: Road traffic accidents (RTAs) are a significant global public health issue, leading to injuries, fatalities, and substantial economic losses. In Nepal, RTAs are a major concern, with notable regional variations in incidence and severity. This study analyzed the spatial distribution and types of road traffic injuries in Nepal from Fiscal Year (FY) 2019-2020 to 2021-2022, focusing on the impact of road types and geographic factors.

Nucleotide-mediated modulation of chemoselective protein functionalization in a liquid-like condensed phase.

Liquid-like protein condensates are ubiquitous in cellular system and are increasingly recognized for their roles in physiological processes. Condensed phase harbors distinctive chemical microenvironment, markedly different than dilute aqueous phase. Herein, we demonstrate chemoselective modification pattern of nucleophilic canonical amino acid sidechains (namely - cysteine, tyrosine and lysine) of the protein towards 4-chloro-7-nitrobenzofurazan in the dilute and condensed phase.

The future in diagnostic tools for TB outbreaks: A review of the approaches with focus on LAMP and RPA diagnostics tests.

Tuberculosis (TB) is still the most frequent cause of morbidity and mortality in the world caused by Mycobacterium tuberculosis (MTB). Due to slow diagnostic and treatment options, the disease is a major concern for public health and also increases the burden on the global economy. Rapid, sensitive, and cheaper TB diagnosis test is urgent to lower their rates by point of care testing (POCT).

Hygiene practice and diarrhea prevalence among underfive children in Myanmar: a cross-sectional study.

Background: Over 1.7 billion instances of diarrheal illness in children are reported worldwide yearly. Diarrhea was a major cause of death in children, accounting for 9% of all global under-five child deaths in 2021.