Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and oral potentially malignant disorders - A comparative cross-sectional South Indian study.

Background: Oral squamous cell carcinoma (OSCC) accounts for nearly 90% of oral malignancies and represents a major global health care problem. It is often preceded by oral potentially malignant disorders (OPMD). Although regular clinical examination forms the backbone for oral cancer screening, subtle lesions go unnoticed and there is a need for more sensitive and specific molecular biomarkers in mass screening of population.

SARS-CoV-2 infections before, during, and after the Omicron wave: a 2-year Indian community cohort study.

Background: We measured the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and re-infections in an adult community-based cohort in southern India.

Methods: We conducted a 2-year follow-up on 1229 participants enrolled between May and October 2021. Participants provided vaccination histories, weekly saliva samples, and blood samples at 0, 6, 12, and 24 months.

Deep Learning and fMRI-Based Pipeline for Optimization of Deep Brain Stimulation During Parkinson's Disease Treatment: Toward Rapid Semi-Automated Stimulation Optimization.

Objective: Optimized deep brain stimulation (DBS) is fast becoming a therapy of choice for the treatment of Parkinson's disease (PD). However, the post-operative optimization (aimed at maximizing patient clinical benefits and minimizing adverse effects) of all possible DBS parameter settings using the standard-of-care clinical protocol requires numerous clinical visits, which substantially increases the time to optimization per patient (TPP), patient cost burden and limit the number of patients who can undergo DBS treatment. The TPP is further elongated in electrodes with stimulation directionality or in diseases with latency in clinical feedback.

The quality of caregiver-child interaction is predicted by (caregivers' perception of) their child's interests.

This current study examines the extent to which children's interests and caregivers' sensitivity to their children's interests are associated with the quality of caregiver-child interaction, and subsequent learning. Eighty-one caregiver-child dyads (24-30-month old children) completed an online shared book-reading task where caregivers and children read two e-books with pictures and descriptions of objects from different categories-one previously determined to be of low and one of high interest to the child (with one novel word-object mapping introduced in each book). We also obtained separate behavioural indices of children's interests and children's later recognition of newly introduced word-object mappings.