Publications by authors named "R Maciulaitis"
Article Synopsis
- Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), and effective treatments for AKI are urgently needed.
- Researchers isolated and characterized human placental mesenchymal stromal cells (hpMSCs) to test their effects in a rat model of AKI, where one group received hpMSCs and others received saline or no treatment.
- The study found that hpMSCs significantly improved kidney function, increased survival rates, and prevented early kidney damage, while also establishing a reliable manufacturing process for these cells.
Article Synopsis
- The link between chronic kidney disease (CKD) and cognitive function is gaining attention, particularly focusing on the effects of antibacterial agents (ABs) used in CKD patients who are more prone to infections.
- This review highlights how ABs can have direct neurotoxic effects on the central nervous system (CNS) and discusses how these medications can also alter gut microbiota, impacting cognitive symptoms through the brain-gut-kidney axis.
- The findings emphasize the need for careful monitoring of AB therapies in CKD patients to manage adverse drug reactions, particularly antibiotic-associated encephalopathy.
Activated and Naïve Allogenic Human Placental Mesenchymal Stromal Cells Exert an Immunomodulatory Effect on Hidradenitis Suppurativa Patient Peripheral Blood Mononuclear Cells.
J Interferon Cytokine Res
July 2024
Article Synopsis
- The pilot study investigated how placental mesenchymal stem/stromal cells (MSCs) affect immune cells from patients with hidradenitis suppurativa (HS) by examining peripheral blood mononuclear cells (PBMCs) from both healthy individuals and HS patients.
- PBMCs from HS patients displayed higher levels of the pro-inflammatory cytokines IL-6 and IFN-γ compared to those from healthy subjects, indicating increased inflammation.
- The study found that co-culture with activated MSCs significantly reduced PBMC proliferation and inflammatory cytokine production, suggesting MSCs may have therapeutic potential for HS, although further research with a larger sample size is needed for confirmation.
: To date, the therapeutic potential of skeletal muscle-derived stem/progenitor cells (MDSPCs) for acute kidney injury (AKI) has only been evaluated by our research group. We aimed to compare MDSPCs with bone marrow mesenchymal stem cells (BM-MSCs) and evaluate their feasibility for the treatment of AKI. : Rats were randomly assigned to four study groups: control, GM (gentamicin) group, GM+MDSPCs, and GM+BM-MSCs.
View Article and Find Full Text PDFThis study investigates the therapeutic potential of human placental mesenchymal stem cells (P-MSCs) and their extracellular vesicles (EVs) in a murine model of acute respiratory distress syndrome (ARDS), a condition with growing relevance due to its association with severe COVID-19. We induced ARDS-like lung injury in mice using intranasal LPS instillation and evaluated histological changes, neutrophil accumulation via immunohistochemistry, bronchoalveolar lavage fluid cell count, total protein, and cytokine concentration, as well as lung gene expression changes at three time points: 24, 72, and 168 h. We found that both P-MSCs and EV treatments reduced the histological evidence of lung injury, decreased neutrophil infiltration, and improved alveolar barrier integrity.
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