Publications by authors named "R Machino"

Article Synopsis
  • Tracheal regeneration is difficult due to its complex structure and limited blood flow; this study introduces scaffold-free artificial tracheas created using bio-3D printing.
  • The artificial tracheas feature hyaline cartilage on the front, developed from mesenchymal stem cells, and smooth muscle on the back, with both tissues successfully cultured and matured.
  • Histological analyses confirmed the proper differentiation of cells, showing that the artificial trachea consists of functional tissues suitable for potential applications in medical regeneration.
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Importance: There is currently no consensus on clinically effective interventions for polypharmacy among older inpatients.

Objective: To evaluate the effect of multidisciplinary team-based medication optimization on survival, unscheduled hospital visits, and rehospitalization in older inpatients with polypharmacy.

Design, Setting, And Participants: This open-label randomized clinical trial was conducted at 8 internal medicine inpatient wards within a community hospital in Japan.

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Primary chest wall tumors are rare, their common clinical features are not well known, and surgical resection remains the main treatment. Apical chest wall tumors require large skin incisions and dissection of the chest wall muscles, making it difficult to maintain cosmetic appearance, respiratory function, and support of the upper extremity. There are few treatment options and no studies have reported on thoracotomy that spares muscles and preserves cosmetic superiority.

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Spontaneous cases of pleural aspergillosis in healthy adults are rare, and the optimal therapeutic approach has not been established. Here we report a rare case of spontaneous pleural aspergillosis in an otherwise healthy young adult. Two-stage surgery with decortication and cavernostomy, followed by systemic antifungal therapy, finally resulted in a successful resolution of his empyema without any serious complications.

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Gastric tube cancer is classically treated with resection through a midline sternal incision. However, because of its invasiveness and limited reconstructive potential, transdiaphragmatic laparoscopic or thoracoscopic dissection of the gastric tube has been investigated. As resection from only the abdominal or thoracic cavity is difficult, we performed surgery with a thoracic surgeon approaching from the thoracic cavity and an abdominal surgeon simultaneously approaching from the cervical and abdominal regions.

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