Publications by authors named "R MOREAU"
Extracellular vesicles (EVs) are cell-derived small membrane structures that transport various molecules. They have emerged as potential circulating biomarkers for monitoring responses to cancer therapies. This study aimed to comprehensively characterize plasma-carried EVs in hormone receptor-positive (HR) metastatic breast cancer (MBC) patients treated with first-line CDK4/6 inhibitors (iCDK4/6) combined with endocrine therapy.
View Article and Find Full Text PDFHaptic simulation of needle insertion requires both a needle-tissue interaction model and a method to render the outputs of this model into real-time force feedback for the user. In comparison with interaction models, rendering methods in the literature have seen little development and are either oversimplified or too computationally complex. Therefore, this study introduces the Generalized Tracking Wall (GTW) approach, a haptic rendering method inspired by the proxy approach.
View Article and Find Full Text PDFArticle Synopsis
- In patients with acutely decompensated cirrhosis (ADC), changes in blood inflammatory markers can indicate a worsening condition, regardless of underlying causes like infections.
- The study categorized 394 ADC patients into four stages of severity and analyzed their blood cell counts and inflammatory markers to see how these factors influenced disease progression.
- Key findings showed that higher neutrophil counts and specific cytokines (IL-25, IL-6, IL-22) were linked to a higher risk of advancing to more severe stages, while lower lymphocyte counts and IFN-γ levels suggested a worse prognosis.
Background & Aims: Patients with acutely decompensated (AD) cirrhosis are immunocompromised and particularly susceptible to infections. This study investigated the immunomodulatory actions of albumin by which this protein may lower the incidence of infections.
Methods: Blood immunophenotyping was performed in 11 patients with AD cirrhosis and 10 healthy volunteers (HV).
Article Synopsis
- - The study evaluates the cost-effectiveness of a cell-based quadrivalent influenza vaccine (QIVc) for people under 65 in France, which could avoid problems related to egg-based vaccines and potentially improve health outcomes.
- - Using a SEIR model based on data from 2011 to 2019, the research found that QIVc could prevent nearly 50,000 GP consultations, over 1,000 hospitalizations, and around 230 deaths compared to the traditional egg-based vaccine (QIVe).
- - Despite an initial cost of 7.6 million euros, QIVc ultimately saves the healthcare system 12 million euros, indicating it is a more effective and cost-saving strategy for influenza vaccination.