Developing Topics.

Background: Previous studies have documented age-related changes in behavior and cognitive functions and investigated the molecular changes in aging brain using inbred mouse strains such as C57BL/6, BALB/c etc. In this study using a genetically heterogenous mouse population (UM-HET3) we investigated age-related changes in motor and memory functions and their association with blood cell measures.

Method: Both male and female UM-HET3 mice at age of 11 months (middle-aged) and 25 months (old) were used in this study.

Diagnostic modalities in the mediastinum and the role of bronchoscopy in mediastinal assessment: a narrative review.

Background And Objective: Diagnosis of pathology in the mediastinum has proven quite challenging, given the wide variability of both benign and malignant diseases that affect a diverse array of structures. This complexity has led to the development of many different non-invasive and invasive diagnostic modalities. Historically, diagnosis of the mediastinum has relied on different imaging modalities such as chest X-ray, computed tomography (CT), magnetic resonance imaging, and positron emission topography.

Calcium-sensing receptor- and ADAM10-mediated klotho shedding is regulated by tetraspanin 5.

Soluble, circulating Klotho (sKlotho) is essential for normal health and renal function. sKlotho is shed from the renal distal convoluted tubule (DCT), its primary source, via enzymatic cleavage. However, the physiologic mechanisms that control sKlotho production, trafficking, and shedding are not fully defined.

Cost-Effectiveness of Semaglutide in Patients With Obesity and Cardiovascular Disease.

Background: Randomized clinical trials have shown that semaglutide is associated with a clinically relevant reduction in body weight and a lower risk of adverse cardiovascular events in those who are overweight or obese with a history of cardiovascular disease but no diabetes. The objective of this study was to assess the cost-effectiveness of semaglutide for this indication.

Methods: A decision analytic Markov model was used to compare the lifetime benefits and costs of semaglutide 2.

Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach.

In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority. To identify potential sepsis drug candidates, we used an optimized larval zebrafish model of endotoxicity/sepsis to screen commercial libraries of drugs approved by the U.