Publications by authors named "R MIHAESCU"
Article Synopsis
- The study focuses on postpartum depression (PPD), a hereditary form of major depressive disorder, using genome-wide association studies (GWAS) to explore its genetic basis across various populations.
- It analyzed data from 18,770 PPD cases and 58,461 controls, finding no single-nucleotide polymorphisms (SNPs) that met genome-wide significance, though it highlighted significant genetic correlations with other mental health conditions.
- The findings suggest that PPD is polygenic and heritable, potentially involving unique genetic factors despite its close relationship with major depressive disorder and implicate specific brain neurons associated with its treatment.
Importance: Evidence of the clinical benefit of pharmacogenetics-informed treatment (PIT) with antidepressants is still limited. Especially for tricyclic antidepressants (TCAs), pharmacogenetics may be of interest because therapeutic plasma concentrations are well defined, identification of optimal dosing can be time consuming, and treatment is frequently accompanied by adverse effects.
Objective: To determine whether PIT results in faster attainment of therapeutic TCA plasma concentrations compared with usual treatment in patients with unipolar major depressive disorder (MDD).
[Psychiatric symptoms and COVID-19: results of a national case register].
Tijdschr Psychiatr
November 2022
Background: Psychiatric disorders are associated with a more severe course of COVID-19. COVID-19 can also lead to psychiatric symptoms.
Aim: To gain insight into vulnerabilities and protective factors for the course of COVID-19 in a Dutch (neuro)psychiatric population.
Introduction: Urinary tract infections (UTIs) are among the most common bacterial diseases of childhood with an increased frequency in infants and young children.
Methods: We conducted a retrospective study of children diagnosed with UTI in the Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania between January 2017 and December 2019. We evaluated the patients' clinical characteristics, laboratory parameters and the resistance profile of the identified uropathogens.
Background: Traditionally tricyclic antidepressants (TCAs) have an important place in treatment of major depressive disorder (MDD). Today, often other antidepressant medications are considered as first step in the pharmacological treatment of MDD, mainly because they are associated with less adverse effects, whereby the position of TCAs appears unclear. In this study we aimed to examine the current practice of TCAs in treatment of unipolar MDD.
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