[Glutathione unit of the antioxidant system activity in pregnant women depending on the sleep quality].

Objective: To assess the enzymatic and non-enzymatic links of the glutathione system in pregnant women depending on the sleep quality.

Material And Methods: The study included 64 pregnant women aged 18 to 40 years. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI).

Association of 3111T/C Polymorphism of the Clock Gene with Circadian Rhythm of Melatonin in Menopausal Women with Insomnia.

We carried out a comparative analysis of circadian rhythms of melatonin secretion in Caucasian menopausal women with and without insomnia depending on the 3111T/C polymorphism of the Clock gene. Melatonin levels was measured in the saliva 4 times a day (06.00-07.

Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia.

A comparative analysis of melatonin circadian rhythms in Caucasian (incoming population) and Asian (indigenous population) menopausal women with/without sleep disorders depending on the genotype of Clock 3111T/C gene polymorphism was realized.The melatonin level in the saliva was determined four times a day (6:00-7:00, 12:00-13:00, 18:00-19:00, 23:00-00:00 h). The Caucasian women-carriers of the TT-genotype with insomnia as compared to control group-had a higher morning melatonin level and a lower night melatonin level.

[Melatonin in therapy of sleep disorders age-related estrogen deficiency].

Aim: To assess quantitative characteristics of sleep in perimenopausal women treated with melatonin in a dose of 3 mg during 3 month.

Material And Methods: A study included 21 perimenopausal women with sleep disorders. Seventeen women completed the study.