Publications by authors named "R M Zancope-Oliveira"
Sporotrichosis during pregnancy: A retrospective study of 58 cases in a reference center from 1998 to 2023.
PLoS Negl Trop Dis
December 2024
Background: Pregnant women constitute a vulnerable population occasionally affected by zoonotic sporotrichosis. Treatment is challenging due to potentially teratogenic oral medications (itraconazole and saturated potassium iodide solution) or lack of clinical experience during pregnancy (terbinafine). Literature is scarce on sporotrichosis and pregnancy, mainly consisting of case reports.
View Article and Find Full Text PDFBackground: Auranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi. The auranofin activity against Histoplasma capsulatum, the dimorphic fungus that causes histoplasmosis, has not been properly addressed. Since there are few therapeutic options for this life-threatening systemic mycosis, this study evaluated the effects of auranofin on H.
View Article and Find Full Text PDFArticle Synopsis
- Zoonotic sporotrichosis, primarily transmitted by cats, has become highly prevalent in Rio de Janeiro, with a study focusing on 43 non-zoonotic cases revealing important epidemiological and clinical data.
- The majority of patients were male and common sources of infection included injuries from plants and soil contact, with a specific fungal species being predominantly responsible for the infections.
- Antifungal susceptibility tests showed some strains resistant to treatment, highlighting the need for ongoing monitoring of antifungal resistance and further investigation into the environmental factors contributing to sporotrichosis.
Article Synopsis
- Sporotrichosis diagnosis requires various tests like culture and serum antibody detection, but these methods can sometimes lead to incorrect results.
- This study focused on different patient groups to determine how well specific antibody tests work, using an ELISA method to check for various antibodies in serum samples.
- Findings indicated that certain patients, especially those with nasal lesions and hypersensitivity, had a higher chance of getting false-negative results in antibody detection, highlighting the diagnostic challenges of sporotrichosis.
A Cluster of Diutina catenulata Funguria in Patients with Coronavirus Disease 2019 (COVID-19) Hospitalized in a Tertiary Reference Hospital from Rio de Janeiro, Brazil.
Curr Microbiol
September 2024
Article Synopsis
- During the COVID-19 pandemic, fungal infections like pulmonary aspergillosis and invasive candidiasis gained attention, with a specific focus on a rare pathogen, Diutina catenulata, isolated from patients' urine.
- A study identified nine strains from six patients needing ventilator support and urinary catheters, all of whom were unvaccinated against COVID-19, and revealed consistent morphological and biochemical profiles among the isolates.
- Whole-genome sequencing showed minimal genetic variation among the strains, suggesting they were part of a cluster of D. catenulata infections associated with COVID-19.