Publications by authors named "R M Wilkins"
Background: Recent advancements in omics and benchmark dose (BMD) modeling have facilitated identifying the dose required for a predetermined change in a response (e.g. gene or protein change) that can be used to establish acceptable dose levels for hazardous exposures.
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- - Cardiovascular diseases (CVDs) involve various heart-related issues, and studies show that high-dose radiotherapy (3-17 Gy) increases CVD risk, but the effects of low radiation doses and space travel on the heart remain unclear.
- - An adverse outcome pathway (AOP) framework was used to study how energy deposition leads to abnormal vascular remodeling, starting with molecular events that create oxidative stress and inflammation, ultimately resulting in endothelial dysfunction.
- - The research aims to fill knowledge gaps regarding the mechanisms of cardiovascular damage from radiation, which could inform future studies and protective strategies for space travelers.
Article Synopsis
- Bone loss, especially prevalent in post-menopausal women and astronauts, involves a decline in bone density and architecture, and is linked to various factors including radiation exposure and cancer treatment.
- Researchers utilized the adverse outcome pathway (AOP) framework to map the process from the initial energy exposure to the resulting bone loss, involving collaborative input from experts in bone health.
- A thorough review of 2029 studies led to an empirically supported AOP that details how changes in osteoblast and osteoclast activity contribute to bone loss, highlighting research gaps and priorities to improve risk assessments for radiation exposure.
Historic recruitment and retention challenges confront the U.S. military.
View Article and Find Full Text PDFClinical Outcomes of a Nurse-Delivered, Technology-Enabled HIV Outpatient Model.
J Int Assoc Provid AIDS Care
September 2024
We evaluated Klick, a nurse-led, digitally enabled model of HIV outpatient care, launched in 2020. Klick's smartphone app offers online booking, remote nurse-led consultations, and results. An audit of Klick nurse-led consultations was conducted against BHIVA monitoring guidelines, and nurses were interviewed about their experience.
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