Publications by authors named "R M Wenham"
Article Synopsis
- The study focused on the post-traumatic reactions and overall quality of life in women who underwent pelvic exenteration (PE) for recurrent gynecologic cancer.
- Out of 21 participants, 30% showed significant signs of post-traumatic stress and 71% had notable depressive symptoms, indicating mental health challenges post-surgery.
- Comparatively, these women's quality of life was lower than the general population but similar to those with advanced ovarian or cervical cancer, highlighting the need for ongoing support and rehabilitation in their recovery.
Objective: Folate receptor alpha (FRα) is overexpressed on >90% of high-grade epithelial ovarian cancers (EOC). Targeting FRα with antibody-drug conjugates has proven utility in the platinum-resistant setting. It is also a potential therapeutic target for immuno-oncologic agents, such as peptide vaccines that work primarily via adaptive and humoral immunity.
View Article and Find Full Text PDFToxicity and emerging drug resistance pose important challenges in poly-adenosine ribose polymerase inhibitor (PARPi) maintenance therapy of ovarian cancer. We propose that adaptive therapy, which dynamically reduces treatment based on the tumor dynamics, might alleviate both issues. Utilizing in vitro time-lapse microscopy and stepwise model selection, we calibrate and validate a differential equation mathematical model, which we leverage to test different plausible adaptive treatment schedules.
View Article and Find Full Text PDFArticle Synopsis
- This study looked at how well a combination of two drugs, cediranib and olaparib, worked for treating ovarian cancer that came back after treatment.
- It involved 70 patients and compared those whose cancer was sensitive to a type of medicine called platinum with those whose cancer was resistant to it.
- The results showed that the drug combo helped patients with sensitive cancer a lot more than those with resistant cancer, but the presence of certain gene mutations didn’t seem to affect how well the drugs worked.
High Financial Hardship among Patients with Advanced Ovarian Cancer.
J Soc Work End Life Palliat Care
June 2024
Article Synopsis
- * This study analyzed financial toxicity (FT) among 38 patients with advanced ovarian cancer, finding that 24% reported clinically significant FT, influenced by factors like income, employment status, and place of birth.
- * The research highlights the need for further studies with larger and more diverse samples to better address the financial challenges faced by these patients and to develop effective interventions.