Publications by authors named "R M Valente"
Breaking the mold: 3D cell cultures reshaping the future of cancer research.
Front Cell Dev Biol
November 2024
Despite extensive efforts to unravel tumor behavior and develop anticancer therapies, most treatments fail when advanced to clinical trials. The main challenge in cancer research has been the absence of predictive cancer models, accurately mimicking the tumoral processes and response to treatments. The tumor microenvironment (TME) shows several human-specific physical and chemical properties, which cannot be fully recapitulated by the conventional 2D cell cultures or the animal models.
View Article and Find Full Text PDFIntraductal papillary mucinous neoplasms (IPMNs) display four histological subtypes: gastric foveolar, pancreaticobiliary, intestinal, and oncocytic. All of these subtypes harbor a different risk of cancer development. The clinical impact of these subtypes concerning the occurrence of high-grade dysplasia (HGD)/cancer (C) in specific morphological types, such as branch-duct (BD), main-duct (MD), and mixed-type (MT) IPMNs, has been less investigated.
View Article and Find Full Text PDFCorrection to "Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells".
J Proteome Res
December 2024
Article Synopsis
- Assessing POP levels in common dolphins helps evaluate environmental health and ecological risks in marine ecosystems.
- The study analyzed biopsy samples from common dolphins in two locations, finding PCBs were the most prevalent organochlorines, with significantly higher levels in Northwest Portugal compared to Madeira Island.
- High PCB concentrations in dolphins from mainland Portugal exceed toxicity thresholds, raising concerns about their physiological effects and indicating poor habitat quality, which could impact overall ecosystem health.