Publications by authors named "R M Tighe"
Article Synopsis
- Air pollution is a public health risk linked to serious health outcomes, and this study investigates how it interacts with viral exposure to influence influenza hospital visits in Ulaanbaatar, Mongolia.
- Researchers analyzed seven years of data on daily influenza-related hospital visits, examining these in relation to various air pollutants, with additional factors considered, such as temperature and humidity.
- The findings showed that air pollution worsens the impact of viral exposure, especially in winter and among children under five, indicating a significant health risk that needs to be addressed.
Article Synopsis
- * The study focused on JEN-101, a localized injection of interleukin-12 designed to boost immune response in dogs with advanced melanoma, evaluating its safety, effectiveness, and immune effects over several doses.
- * Results indicated that JEN-101 was well-tolerated with manageable side effects, and it showed promising biological responses, suggesting its potential for further research and relevance to human cancer treatment.
Asthma is a widespread chronic lung disease characterized by airway inflammation and hyperresponsiveness. This airway inflammation is classified by either the presence (T2-high) or absence (T2-low) of high levels of eosinophils. Because most therapies for asthma target eosinophils and related pathways, treatment options for T2-low disease are limited.
View Article and Find Full Text PDFBackground: Airway tissue eosinophilia can be an observed feature of obesity-associated type 2 (T2) asthma, but the processes mediating this inflammation are unknown.
Objective: To investigate a process whereby leptin, an adipokine elevated in obesity, potentiates pulmonary eosinophilia and eotaxin production by airway fibroblasts in T2 asthma.
Methods: We assessed associations between body mass index and airway eosinophilia as well as leptin and eotaxin production in 78 participants with asthma, 36 of whom exhibited obesity.