Quercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone.

Background: Cellular histones are DNA-binding nuclear proteins involved in chromatin remodelling and regulation of gene expression. However, extracellular histones act as damage-associated molecular patterns (DAMPs) and contribute to multiorgan damage in conditions with sepsis and diseases with acute critical illnesses. Alongside, histones are associated with thrombocytopenia due to dysfunctional platelets that regulate hemostasis and thrombosis.

Counteraction of unconjugated bilirubin against heme-induced toxicity in platelets.

Platelets are essential for normal hemostasis and thrombosis but become hyperactive in hemolytic disorders. Cell-free heme is known to be toxic to platelets and endothelial cells, playing a significant role in the progression of pathological complications in various hemolytic conditions. The abnormal activation of circulatory platelets results in micro/macrovascular thrombosis and clot formation in the lungs, worsening the disease.

Gold(I) Catalysis in Alkyne-Alkene Reactions: A Systematic Exploration through Molecular Electrostatic Potential Analysis.

Gold catalysis enables selective chemical transformations with catalytic activity tunable through ligand selection. This study uses the density functional theory (DFT) to explore the impact of phosphine ligands (PR) on gold(I)-catalyzed alkyne-alkene cyclobutene formation. We analyze the following key steps: (i) PR-Au complexation, (ii) alkyne binding, (iii) alkene binding, (iv) C-C coupling transition state, (v) cyclobutene formation transition state, and (vi) cyclobutene dissociation.

Diagnostic Accuracy of Standalone T2 Dixon Sequence Compared with Conventional MRI in Sacroiliitis.

 The aim of this article was to assess the profile of T2-weighted (T2W) multipoint Dixon sequence and conventional sequences in magnetic resonance imaging (MRI) of sacroiliac joints for the diagnosis of active and chronic sacroiliitis.  Prospective observational study.  Thirty-seven patients with sacroiliitis underwent MRI with conventional coronal oblique short tau inversion recovery, T1W sequences, and T2W multipoint Dixon sequences.

Diffusion weighted imaging in breast cancer - Can it be a noninvasive predictor of nuclear grade?

Background: DWI and ADC values are noninvasive MRI techniques, which provide quantitative information about tumor heterogeneity.

Aim: To determine the minimum and mean ADC values in breast carcinoma and to correlate ADC values with various prognostic factors.

Settings And Design: Prospective observational study.