Publications by authors named "R M Thaler"
Background: Native and periprosthetic joint infections are devastating conditions fraught with patient morbidity and mortality. Aseptic and septic joints are often debrided and irrigated to decrease bacterial loads when preventing or treating infection. However, the effect of clinically used irrigation solutions on the native cellular components of the synovial joint is unknown.
View Article and Find Full Text PDFThis study aimed to evaluate the effects of dietary fat source and feeding duration on growth performance, carcass characteristics, and meat quality of finishing pigs. A total of 450, 21-wk-old finishing pigs with an average body weight of 113.7 ± 8 kg were housed in 90 pens assigned to one of five dietary treatments in a 2 × 2 + 1 factorial design.
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- - Obesity negatively affects mesenchymal stem/stromal cells (MSCs), leading to tissue degeneration and lower healing potential, with unclear underlying mechanisms regarding mitochondrial gene alterations.
- - A study compared MSCs from obese and non-obese individuals, revealing significant changes in hydroxymethylcytosine (5hmC) profiles and gene expression related to mitochondrial function, impacting processes like cell survival, energy production, and neuron formation.
- - Findings showed that obese MSCs had structural and functional mitochondrial impairments, which could be partially reversed through epigenetic modulation, highlighting potential pathways for developing therapies to combat obesity-related health issues.
Aims: Embolic stroke of undetermined source (ESUS) accounts for up to 20% of ischemic strokes annually. Undetected atrial fibrillation (AF) is one important potential underlying cause. For AF, oral anticoagulation has evolved as the most preferable means of secondary stroke prevention.
View Article and Find Full Text PDFNew clathrochelate complexes of manganese, iron and cobalt containing peripheral organometallic manganese moieties cymantrene or tromancenium were synthesized via self-assembly from di/tri-topic dioximes, metal templates and cymantrene/tromancenium boronic acid pinacol esters. These air-stable, highly colored, oligometallic complexes are composed of various combinations of MnFeMn, MnCoMn, MnMnMnMn and MnCoCoMn metal assemblies with corresponding complicated magnetic and electrochemical properties. Full spectroscopic and structural characterization by H/B/C NMR, HRMS, IR, UV-vis, single crystal XRD and CV (cyclic voltammetry) is provided.
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