Publications by authors named "R M Tate"
New Disability in a Cohort Study of Older Men-The Manitoba Follow-Up Study.
Can Geriatr J
December 2024
Background: There is a large literature on the prevalence of disability in older men, but less data on the incidence of new disability.
Objectives: 1. To determine the incidence of moderate-to-severe disability in a prospective cohort study of aging men; and 2.
Article Synopsis
- The study investigates the relationships between sleep quality, global mental status, and the risk of mortality, using data from 1364 participants in the HANDLS study over approximately 8 years.
- Results indicate that poorer sleep quality is linked to a higher mortality risk, particularly among individuals with initially better cognitive function.
- The findings suggest a complex interaction between sleep and cognition affecting mortality risk, highlighting the need for further research to explore these connections over time.
Background: Gene therapy is a promising therapeutic approach for treating various disorders by introducing modified nucleic acids to correct cellular dysfunctions or introduce new functions. Despite significant advancements in the field, the effective delivery of nucleic acids remains a challenge, due to biological barriers and the immune system's ability to target and destroy these molecules. Due to their branched structure and ability to condense negatively charged nucleic acids, cationic dendrimers have shown potential in overcoming these challenges.
View Article and Find Full Text PDFBackground: Evidence points to associations between sleep quality, dementia, and mortality. We examined whether poor sleep quality mediated or moderated the association between dementia and mortality risk among older US adults and vice versa, and whether these associations differed by sex and by race.
Methods: The study investigated bi-directional associations between sleep quality, dementia and mortality in older US adults using data from the Health and Retirement Study ( = 6,991, mean age = 78.