Publications by authors named "R M Swenson"
The worldwide frequency of head and neck squamous cell carcinoma (HNSCC) is approximately 800,000 new cases, with 430,000 deaths annually. We determined that LZK (encoded by ) is a therapeutic target in HNSCC and showed that inhibition with small molecule inhibitors decreases the viability of HNSCC cells with amplified . A drug-resistant mutant of LZK blocks decreases in cell viability due to LZK inhibition, indicating on-target activity by two separate small molecules.
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- The study investigates the use of mini-fragment implants versus small-fragment implants for open reduction and internal fixation (ORIF) of ankle fractures, aiming to determine if mini-fragments lead to lower rates of elective implant removal and complications.
- It analyzed data from 505 patients, finding similar rates of elective implant removal (8.3% for mini-fragment vs. 10.8% for small-fragment) and complication rates (6.7% for mini-fragment vs. 6.5% for small-fragment).
- The authors conclude that while mini-fragment implants are popular, their higher cost must be weighed against their similar effectiveness to small-fragment implants in terms of implant removal and complications.
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- Peptides are crucial for many biological processes, leading to increased interest in tracking their metabolism in living organisms.
- Dissolution-dynamic nuclear polarization (d-DNP) enhances nuclear magnetic resonance (NMR) sensitivity, allowing researchers to gather metabolic and physiological data in real-time.
- This study reveals the successful in vivo detection of metabolic changes in hyperpolarized C-oligopeptides, showing significant alterations in C-glutathione in mouse kidneys affected by acute kidney injury.
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- Distal tibia shaft fractures often accompany posterior malleolar fractures (PMFs), leading to routine preoperative ankle CT scans to assess damage.
- A study analyzed data from 124 patients with these fractures, comparing outcomes between those who received CT scans and those who did not, but found no significant differences in key outcomes.
- While CT scans helped identify some PMFs that weren't visible on regular x-rays, they did not improve surgical efficiency or reduce complications related to PMFs.
Introduction: Alzheimer's disease and related dementias (ADRD) represent a substantial global public health challenge with multifaceted impacts on individuals, families, and healthcare systems. Brief cognitive screening tools such as the Mini-Cog© can help improve recognition of ADRD in clinical practice, but widespread adoption continues to lag. We compared the Digital Clock and Recall (DCR), a next-generation process-driven adaptation of the Mini-Cog, with the original paper-and-pencil version in a well-characterized clinical trial sample.
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