Publications by authors named "R M Singaporewalla"
Performance of a multigene genomic classifier and clinical parameters in predicting malignancy in a Southeast Asian cohort of patients with cytologically indeterminate thyroid nodules.
Samantha Peiling Yang Min En Nga Manish Mahadeorao Bundele Simion I Chiosea Sze Hwa Tan Reyaz M Singaporewalla
Cancer Cytopathol
May 2024
Article Synopsis
- Most thyroid nodules are benign, but differentiating between benign and malignant nodules can prevent unnecessary surgeries; this study focused on a genetic classifier's performance for indeterminate thyroid nodules in Southeast Asia.
- The study involved 132 patients and utilized ThyroSeq v3 for molecular testing on FNA samples, revealing that 56% of the nodules were histologically malignant, with varying mutation characteristics compared to North American patients.
- The genomic testing showed a 42% potential avoidance of surgery for patients with Bethesda category III-IV nodules, indicating that molecular testing was a stronger predictor of malignancy than traditional clinical factors.
It is important for the clinician to be familiar with interpreting a variety of radiological modalities that provide vital information that will aid in the preoperative planning, counseling, and subsequent management of patients with retrosternal goiter.
View Article and Find Full Text PDFBackground: Minimally invasive video-assisted thyroidectomy (MIVAT) although well established in Europe has not yet gained widespread acceptance in Asia. We describe our learning experience in the first reported series of 105 cases from Singapore.
Methods: A retrospective analysis of outcomes in 105 patients who underwent MIVAT from April 2011 to 2018 was performed.