Publications by authors named "R M Santella"
Article Synopsis
- Breast cancer (BC) is the most common cancer among women, and metabolomics could help explain the rising incidence beyond known risk factors.* -
- A study involving 40 BC cases and 70 controls identified eight metabolic features linked to BC risk, though statistical significance was lost after accounting for multiple comparisons.* -
- Incorporating these metabolic features into predictive models improved breast cancer risk assessment accuracy significantly, suggesting potential for future research in larger cohorts.*
Article Synopsis
- - The study aimed to replicate a previous finding that EDTA-based chelation therapy reduces cardiovascular disease (CVD) events in individuals with diabetes and a history of myocardial infarction (MI).
- - Conducted at 88 sites in the US and Canada, the trial involved 959 participants who were randomly assigned to receive either chelation therapy or a placebo, with a median follow-up of 48 months.
- - Results showed no significant difference in CVD events between the chelation group (35.6% experienced a primary event) and the placebo group (35.7%), indicating that chelation may not provide the hoped-for benefits in this population.
Aberrant DNA methylation patterns have been used for cancer detection. However, DNA hemi-methylation, present at about 10% CpG dinucleotides, has been less well studied. Here we show that a majority of differentially hemi-methylated regions (DHMRs) in liver tumor DNA or plasma cells free (cf) DNA do not overlap with differentially methylated regions (DMRs) of the same samples, indicating that DHMRs could serve as independent biomarkers.
View Article and Find Full Text PDFBackground: The reduction in cardiovascular disease (CVD) events with edetate disodium (EDTA) in the Trial to Assess Chelation Therapy (TACT) suggested that chelation of toxic metals might provide novel opportunities to reduce CVD in patients with diabetes. Lead and cadmium are vasculotoxic metals chelated by EDTA. We present baseline characteristics for participants in TACT2, a randomized, double-masked, placebo-controlled trial designed as a replication of the TACT trial limited to patients with diabetes.
View Article and Find Full Text PDFBackground And Aims: Despite the substantial impact of environmental factors, individuals with a family history of liver cancer have an increased risk for HCC. However, genetic factors have not been studied systematically by genome-wide approaches in large numbers of individuals from European descent populations (EDP).
Approach And Results: We conducted a 2-stage genome-wide association study (GWAS) on HCC not affected by HBV infections.