[The winning works of the Scientific Council of the Israel Medical Association (IMA) Award for Excellence in Basic Sciences for 2024].

The winning works of the Scientific Council of the Israel Medical Association (IMA) Award for Excellence in Basic Sciences for 2024.

Mapping Research Trends in One Health: A Comprehensive Review.

The One Health approach, which emphasizes the interconnection between human, animal, plant, and environmental health, has gained significant attention as a framework for addressing global health challenges. This study presents a thorough bibliometric analysis of One Health research, utilizing the Web of Science Core Collection database, covering the period from 1989 to 2024. The analysis uncovers a substantial increase in scientific output over the years, reflecting the growing importance of this interdisciplinary field.

Acute Metabolic Decompensation of Isovaleric Acidemia Presenting as Persistent Metabolic Acidosis in a Middle-Aged Man: A Case Report.

Isovaleric acidemia is a rare autosomal recessive inborn error of metabolism that affects the breakdown of the essential amino acid leucine. Acute metabolic decompensation is often triggered by stressors such as surgery, concurrent illness, excessive protein intake, or dehydration. This can lead to a catabolic state with increased endogenous protein turnover, posing a risk of potentially life-threatening crises due to the accumulation of toxic metabolites from incomplete leucine breakdown.

UNSEG: unsupervised segmentation of cells and their nuclei in complex tissue samples.

Multiplexed imaging technologies have made it possible to interrogate complex tissue microenvironments at sub-cellular resolution within their native spatial context. However, proper quantification of this complexity requires the ability to easily and accurately segment cells into their sub-cellular compartments. Within the supervised learning paradigm, deep learning-based segmentation methods demonstrating human level performance have emerged.