Publications by authors named "R M Ransohoff"
Selected Aspects of the Neuroimmunology of Cell Therapies for Neurologic Disease: Perspective.
Neurol Neuroimmunol Neuroinflamm
January 2025
Neurologic disease remains a cause of incalculable suffering, a formidable public health burden, and a wilderness of complex biology and medicine. At the same time, advances in basic science, technology, and the clinical development toolkit bring meaningful benefit for patients along with realistic hope for those whose conditions remain inadequately treated. This perspective focuses on cell-based therapies for neurologic disease, with particular emphasis on neuroimmunologic disorders and on the immunologic considerations of cell therapy for nonimmune conditions.
View Article and Find Full Text PDFOver a decade ago, it was discovered that microglia, the brain's immune cells, engulf synaptic material in a process named microglial pruning. This term suggests that microglia actively sculpt brain circuits by tagging and phagocytosing unwanted synapses. However, live imaging studies have yet to demonstrate how microglial synapse elimination occurs.
View Article and Find Full Text PDFArticle Synopsis
- Research highlights the significant role of immune processes in the development of Alzheimer's disease, which is the leading cause of dementia.
- Various studies indicate that both innate and adaptive immune responses contribute to the disease's pathology and are influenced by genetics and lifestyle factors.
- New therapeutic approaches targeting neuroinflammation are being explored in clinical settings, offering potential treatment options for Alzheimer's patients.
Article Synopsis
- The study investigates the role of yolk-sac-derived microglia in Alzheimer's disease (AD), focusing on the gene ADGRG1 and its impact on microglial protective responses.
- Microglial deficiency of ADGRG1 was shown to increase amyloid plaque buildup, worsen brain pathology, and speed up cognitive decline in mouse models.
- The findings suggest that targeting microglial functioning, particularly through ADGRG1, could lead to new treatments to slow down the progression of Alzheimer's disease.
Article Synopsis
- Researchers Gao, Kim, and their team found that certain clonal populations of CD4 T cells appear in mice following spinal cord injury (SCI).
- Some of these T cell clones were linked to better motor recovery and a reduction in inflammation.
- This discovery could lead to new cell therapy approaches for SCI, which currently has only supportive treatment options.