Publications by authors named "R M R Burbano"
A systematic review and meta-analysis of users versus non-users: unveiling the influence of proton pump inhibitors on capecitabine efficacy in colorectal cancer.
Expert Rev Clin Pharmacol
December 2024
Introduction: Colorectal cancer is the second leading cause of cancer-related deaths worldwide. The impact of proton pump inhibitors (PPIs) on patients taking capecitabine, an oral fluoropyrimidine, remains uncertain, despite their use by 20 to 55% of cancer patients. We investigated how PPIs affect the effectiveness of capecitabine in treating colorectal cancer.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) and polypoid syndromes are significant public health concerns, with somatic mosaicism playing a crucial role in their genetic diversity. This study aimed to investigate the prevalence and impact of somatic mosaicism in these conditions.
Methods: A search was conducted using PubMed, Scopus, and Web of Sciences to identify studies evaluating mosaicism in patients with CRC or polyposis syndromes.
Impact of ABCG2 rs2231142(421C>A) Variant on the Clinical Outcomes of Patients With -mutated Non-small Cell Lung Cancer Treated With Gefitinib: A Comprehensive Meta-analysis.
Anticancer Res
December 2024
Background/aim: Lung cancer accounts for the largest percentage of cancer deaths worldwide, with non-small cell lung cancer (NSCLC) being the predominant type. Gefitinib, an EGFR tyrosine kinase inhibitor (EGFR-TKI), has shown marked efficacy in NSCLC patients with an EGFR mutation. However, gefitinib resistance because of ABCG2 polymorphisms such as rs2231142(421C > A) might limit its clinical use.
View Article and Find Full Text PDFTranscriptome analysis displays new molecular insights into the mechanisms of action of Mebendazole in gastric cancer cells.
Comput Biol Med
January 2025
Gastric cancer (GC) is a common cancer worldwide. Therefore, searching for effective treatments is essential, and drug repositioning can be a promising strategy to find new potential drugs for GC therapy. For the first time, we sought to identify molecular alterations and validate new mechanisms related to Mebendazole (MBZ) treatment in GC cells through transcriptome analysis using microarray technology.
View Article and Find Full Text PDFPrevalence of cardiometabolic outcomes in women who underwent salpingo-oophorectomy to prevent hereditary breast and ovarian cancer: a meta-analysis.
Fam Cancer
November 2024
Article Synopsis
- Risk reduction salpingo-oophorectomy (RRSO) is a surgery often performed on women with hereditary breast and ovarian cancer (HBOC) syndrome caused by BRCA1 and BRCA2 mutations, which leads to surgical menopause and potential health risks.
- A meta-analysis of six studies involving 1,320 patients examined the rates of cardiovascular and metabolic conditions post-surgery, including myocardial infarction, hypertension, hypercholesterolemia, and type 2 diabetes.
- The results showed that while there were increased prevalence rates for conditions like hypertension (28%) and hypercholesterolemia (27.2%), the overall cardiovascular risk did not significantly increase for women undergoing RRSO.