Publications by authors named "R M Prieto"
Background: The complex aetiology of type 1 diabetes (T1D), characterised by a detrimental cross-talk between the immune system and insulin-producing beta cells, has hindered the development of effective disease-modifying therapies. The discovery that the pharmacological activation of LRH-1/NR5A2 can reverse hyperglycaemia in mouse models of T1D by attenuating the autoimmune attack coupled to beta cell survival/regeneration prompted us to investigate whether immune tolerisation could be translated to individuals with T1D by LRH-1/NR5A2 activation and improve islet survival.
Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from individuals with and without T1D and derived into various immune cells, including macrophages and dendritic cells.
Juveniles of interspecific avian brood parasites need to locate and recognize conspecifics to continue their life cycle after being reared by individuals of another species. However, little is known about the recognition mechanisms and cues involved in this critical stage of their lives. It has been proposed that adult parasites could show some kind of parental behavior by actively searching and interacting with conspecific young, which in turn could serve the juveniles to learn and/or reinforce the learning of conspecific characteristics.
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- - Papillary craniopharyngioma (PCP) is a rare, benign tumor that accounts for about 20% of craniopharyngioma cases, primarily affecting adults and linked with the hypothalamus, presenting challenges in both diagnosis and surgical treatment due to its location.
- - Symptoms often involve visual deficits and psychiatric issues in about 45% of patients, with MRI being effective for detection but finding only half of the cases; surgical approaches vary, with endoscopic endonasal techniques offering better outcomes.
- - Most PCPs have the BRAFV600E mutation, which activates a key cellular signaling pathway, suggesting they may respond positively to targeted therapies like BRAF/MEK inhibitors, as shown in a recent
Background & Aims: Fontan-type surgery is a palliative procedure for congenital heart disease with univentricular physiology that may, in the long term, lead to advanced chronic liver disease. Herein, we assessed the accuracy of conventional non-invasive models for assessing liver fibrosis in the context of Fontan circulation and developed a new risk score employing non-invasive tools.
Methods: A prospective, cross-sectional, observational study was conducted across five European centers and encompassing all consecutive adult patients with Fontan circulation, liver biopsy and non-invasive tests (e.