Alternating Magnetic Field Generation and Interaction with Magnetic Polyelectrolyte Microcapsules.

Layer-by-Layer (LbL) microcapsules with iron oxide nanoparticles facilitate smart drug delivery in the presence of an alternating magnetic field. A high-frequency alternating magnetic field (AMF) has been commonly used to induce hyperthermia for killing tumor tissues. This technique, however, could harm normal tissues.

Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells.

Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAFV600E mutation, which constitutively activates the MAPK pathway, a key driver of cell growth. Although combining BRAF and MEK inhibitors can shrink tumors, resistance often develops.

The Incidence and Consequences of Endovascular Technical Failure in Patients with Chronic Limb Threatening Ischemia: Results from the BEST-CLI Trial.

Purpose: To analyze the causes and clinical impacts of endovascular technical failure (ETF) in the BEST-CLI trial, which compared endovascular therapy to bypass surgery in patients with chronic limb-threatening ischemia (CLTI) METHODS: Patients with CLTI were randomized to infrainguinal bypass or endovascular therapy. ETF was defined as the inability to complete the endovascular procedure. Patients with ETF were compared with no ETF.

Exercise rehabilitation for people with postural tachycardia syndrome at two secondary care centres in the UK: the PULSE feasibility randomised controlled trial.

Objectives: The aim of the study was to assess the feasibility of conducting a definitive multicentre randomised controlled trial (RCT) testing an online exercise rehabilitation and behavioural/motivational support intervention for people with postural tachycardia syndrome (PoTS).

Design: Feasibility RCT.

Setting: Two secondary care centres.