Publications by authors named "R M Phelps"
Mismatch repair (MMR) deficiency can be indicative of Lynch syndrome (LS) and guide treatment with immune checkpoint inhibitors. Colorectal cancers (CRCs) and endometrial cancers (ECs) are routinely screened to identify LS, primarily using immunohistochemistry (IHC) or microsatellite instability (MSI) testing, but concordance between these methods is variable in ECs. Here, we investigate this variability in 361 ECs from the Ohio OCCPI/OPTEC ( = 196) and Manchester PETALS ( = 165) trials, where concordance between assays differed significantly.
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- Many children with disabilities do not receive Early Intervention (EI) services despite automatic eligibility due to limited knowledge and use of established conditions lists among pediatricians and EI personnel.
- A study involving surveys and interviews showed that pediatricians generally felt less informed about these lists compared to EI staff, leading to underutilization in making referrals and determining eligibility.
- Recommendations include enhancing the content of these lists and improving their accessibility and distribution to ensure eligible children receive the necessary services.
Background: Impact of Merkel cell polyomavirus (MCPyV) associated Merkel cell carcinoma (MCC) has not been assessed in the Icelandic population, nor in a whole population elsewhere.
Objectives: The primary objective was to assess trends in the incidence of MCC in Iceland and the association with MCPyV. Secondary objectives aimed to analyze MCC outcomes.