J Antimicrob Chemother
November 2024
Objectives: In England, group B streptococci (GBS; Streptococcus agalactiae) are considered universally susceptible to penicillin. Reports from Africa, Asia, North America and a few European countries have described GBS isolates with penicillin MICs above the epidemiological cut-off (0.125 mg/L).
View Article and Find Full Text PDFCrystals of the title salt, (CHN)[Sn(CH)(CHOS)], comprise diisobutyl-ammonium cations and mercapto-acetato-tri-phenyl-stannate(IV) anions. The bidentate binding mode of the mercapto-acetate ligand gives rise to a five-coordinated, ionic tri-phenyl-tin complex with a distorted -trigonal-bipyramidal geometry around the tin atom. In the crystal, charge-assisted ammonium-N-H⋯O(carboxyl-ate) hydrogen-bonding connects two cations and two anions into a four-ion aggregate.
View Article and Find Full Text PDFThe steric interference of proximal dialkyl amino and acyl groups at the peri (1,8) positions of naphthalene affects the intramolecular charge transfer fluorescence. Previous studies indicate that acyl and freely rotating dimethyl amino groups twist toward coplanarity with the naphthalene ring in the excited state. The present study examines the effect of constraining the amino group in a ring.
View Article and Find Full Text PDFReactions of BiI/CuI mixtures with tetrahydrothiophene (THT) in toluene produce 2-D sheet networks BiCuI(THT) ( = 2, 3, or 4), depending on reaction conditions. All three structures are based on BiI octahedra, which share pairs of (μ-I) with Cu(THT) units. BiCuI(THT) features Cu(μ-I) rhombs with close Cu···Cu interactions and is accompanied by formation of the very complex HBiCuI(THT).
View Article and Find Full Text PDFThe activation of the CP/LP C3 proconvertase complex is a key event in complement activation and involves cleavage of C4 and C2 by the C1s protease (classical pathway) or the mannose-binding lectin-associated serine protease (MASP)-2 (lectin pathway). Efficient cleavage of C4 by C1s and MASP-2 involves exosites on the complement control protein and serine protease (SP) domains of the proteases. The complement control protein domain exosite is not involved in cleavage of C2 by the proteases, but the role of an anion-binding exosite (ABE) on the SP domains of the proteases has (to our knowledge) never been investigated.
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