Publications by authors named "R M PAINE"
Purpose To assess the repeatability of real-time cine pulmonary MRI measures of metronome-paced tachypnea (MPT)-induced dynamic hyperinflation and its relationship with chronic obstructive pulmonary disease (COPD) severity. Materials and Methods SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) (ClinicalTrials.gov identifier no.
View Article and Find Full Text PDFBackground/objectives: Both aging and chronic obstructive pulmonary disease (COPD) are strongly associated with changes in the metabolome; however, it is unknown whether there are common aging/COPD metabolomic signatures and if accelerated aging is associated with COPD.
Methods: Plasma from 5704 subjects from the Genetic Epidemiology of COPD study (COPDGene) and 2449 subjects from Subpopulations and intermediate outcome measures in COPD study (SPIROMICS) were profiled using the Metabolon global metabolomics platform (1013 annotated metabolites). Post-bronchodilator spirometry measures of airflow obstruction (forced expiratory volume at one second (FEV)/forced vital capacity (FVC) < 0.
Among tobacco-exposed persons with preserved spirometry (TEPS), we previously demonstrated that different lung volume indices, specifically elevated total lung capacity (TLC) versus elevated ratio of functional residual capacity-to-TLC (FRC/TLC), identify different lung disease characteristics in the COPDGene cohort. Determine differential disease characteristics and trajectories associated with the lung volume indices among TEPS in the SPIROMICS cohort. We categorized TEPS (n=814) by tertiles (low, intermediate, high) of TLC or residual volume-to-TLC (RV/TLC) derived from baseline CT images, and then examined clinical and spirometric disease trajectories in mutually exclusive categories of participants with high TLC without high RV/TLC ([TLC]) versus high RV/TLC without high TLC ([RV/TLC]).
View Article and Find Full Text PDFSerum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS.
Am J Respir Crit Care Med
October 2024
Article Synopsis
- Serum IgG deficiency is linked to increased risks of exacerbations in chronic obstructive pulmonary disease (COPD), but the impact of lower normal range levels is uncertain.
- A study involving 1,497 smokers analyzed the relationship between serum IgG levels and COPD exacerbations, finding that levels below the 35th percentile (1225 mg/dL) heightened exacerbation risk.
- Specifically, low levels of IgG1 and IgG2 subclasses were significantly correlated with severe exacerbations, indicating that even mild impairments in IgG can affect disease severity in at-risk individuals.
Article Synopsis
- Researchers are investigating how artificial intelligence (AI) can help measure functional small airways disease (fSAD) in chronic obstructive pulmonary disease (COPD) using just one CT scan instead of the two traditionally required.
- They studied over 2,500 participants and found strong correlations between the new AI method and existing measures of lung function, confirming its effectiveness.
- The new AI technique for estimating fSAD proved to be more reliable and repeatable compared to standard methods, suggesting it could enhance clinical assessments of COPD.