Developing an Australian Value Set for the Recovering Quality of Life-Utility Index (ReQoL-UI) instrument using Discrete Choice Experiment with Duration.

Objectives: The Recovering Quality of Life-Utility Index (ReQoL-UI) instrument was designed to measure the quality of life outcomes for people over 16 years of age with mental health problems. We aim to elicit societal preferences for the ReQoL-UI health states to facilitate better decision-making in Australia.

Methods: A discrete choice experiment (DCE) with duration was embedded in a self-complete online survey and administered to a representative sample (n=1019) of the Australian adult population aged 18 years and more, stratified for age, sex and geographic location.

Nuclear Alpha-Synuclein in Parkinson's Disease and the Malignant Transformation in Melanoma.

Alpha-synuclein (ASyn), a marker of Parkinson's disease (PD) and other neurodegenerative processes, plays pivotal roles in neuronal nuclei and synapses. ASyn and its phosphorylated form at Serine 129 (p-ASyn) are involved in DNA protection and repair, processes altered in aging, neurodegeneration, and cancer. To analyze the localization of p-ASyn in skin biopsies of PD patients and melanoma.

Relationship between language comprehension and chronic neurobehavioral symptoms in adults with mild traumatic brain injury.

Primary Objectives: Annually, millions of Americans sustain mild traumatic brain injuries (mTBI), and some may experience neurobehavioral symptoms (NBS), like slow processing speed that persist chronically or longer than 6 months post injury. In turn, cognitive processes like language comprehension may be compromised. This study investigates the relationship between NBS and language comprehension in individuals with mTBI history and low or high NBS.

The Gift of Time, How Do I Want to Spend It? Exploring Preferences for Time Allocation Among Women with and without a Breast Cancer Diagnosis.

Background: Women's preferences for time allocation reveal how they would like to prioritise market work, family life, and other competing activities. Whilst preferences may not always directly translate to behaviour, they are an important determinant of intention to act.

Objective: We present the first study to apply a discrete choice experiment (DCE) to investigate time allocation preferences among women diagnosed with breast cancer and women without a cancer diagnosis.

Emerging therapeutic strategies to mitigate female and male reproductive aging.

People today are choosing to have children later in life, often in their thirties and forties, when their fertility is in decline. We sought to identify and compile effective methods for improving either male or female fertility in this context of advanced reproductive age. We found few clinical studies with strong evidence for therapeutics that mitigate reproductive aging or extend fertility; however, this Perspective summarizes the range of emerging experimental strategies under development.