Risk assessment of parabens in a transcriptomics-based in vitro test.

Parabens have been used for decades as preservatives in food, drugs and cosmetics. The majority however, were banned in 2009 and 2014 leaving only methyl-, ethyl-, propyl-, and butyl-derivates available for subsequent use. Methyl- and propylparaben have been extensively tested in vivo, with no resulting evidence for developmental and reproductive toxicity (DART).

Building a library of source samples for sediment fingerprinting - Potential and proof of concept.

Purpose: Sediment fingerprinting of fluvial targets has proven useful to guide conservation management and prioritize sediment sources for Federal and State supported programs in the United States. However, the collection and analysis of source samples can make these studies unaffordable, especially when needed for multiple drainage basins. We investigate the potential use of source samples from a basin with similar physiography (using samples from one of a "pair" to evaluate samples from the other) or combined from multiple basins (a "library").

Watershed- and reach-scale drivers of phosphorus retention and release by streambed sediment in a western Lake Erie watershed during summer.

Reducing phosphorus (P) concentrations in aquatic ecosystems, is necessary to improve water quality and reduce the occurrence of harmful cyanobacterial algal blooms. Managing P reduction requires information on the role rivers play in P transport from land to downstream water bodies, but we have a poor understanding of when and where river systems are P sources or sinks. During the summers of 2019 and 2021, we sampled streambed sediment at 78 sites throughout the Maumee River network (a major source of P loads to Lake Erie) focusing on the zero equilibrium P concentration (EPC), the soluble reactive phosphorus (SRP) concentration at which sediment neither sorbs nor desorbs P.

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment - A case study with parabens.

Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with propylparaben (PP) demonstrates a 10-step read-across (RAX) framework in practice. It aims at establishing a proof-of-concept for the value added by new approach methodologies (NAMs) in read-across (RAX) for use in a next-generation risk assessment (NGRA) in order to assess consumer safety after exposure to PP-containing cosmetics.

Phosphorus sources, forms, and abundance as a function of streamflow and field conditions in a Maumee River tributary, 2016-2019.

Total phosphorus (TP), dissolved P (DP), and suspended sediment (SS) were sampled in Black Creek, Indiana, monthly during base flow and for 100 storm events during water years 2016-2019, enabling analysis of how each of these varied as a function of streamflow and field conditions at nested edge-of-field sites. Particulate P was normalized for SS (P  = [TP - DP]/SS). Streamflow events were differentiated by maximum TP concentrations co-occurring with maximum SS (SED) or DP (SOL).