Publications by authors named "R M Kream"
Article Synopsis
- Mitochondria, once thought to be purely dependent organelles formed from bacteria about 1.45 billion years ago, are now recognized for their functional independence and ability to operate outside of cells.
- Recent studies reveal that mitochondria engage in complex interactions with each other and other cellular components, similar to how bacteria communicate through quorum sensing.
- This new perspective on mitochondria suggests that they should be studied as independent entities, which could lead to innovative treatments for diseases linked to mitochondrial dysfunction.
Article Synopsis
- Prions are infectious proteins that cause neurodegenerative diseases like Creutzfeldt-Jakob disease, differing from viruses and bacteria as they lack a nucleic acid genome.
- They lead to neuronal loss and abnormal protein folding, resulting in memory issues, personality changes, and various cognitive impairments.
- The text suggests that long COVID could be linked to prion-like mechanisms, particularly in those vulnerable to such changes, explaining some post-viral infection symptoms.
Article Synopsis
- * ROS are linked to neuropsychiatric disorders, such as schizophrenia and bipolar disorder, by potentially damaging cognitive functions due to their impact on brain energy supply.
- * The study suggests that mitochondrial dysfunction may underlie cognitive issues and psychiatric symptoms, positing that these symptoms could be remnants of ancient evolutionary processes promoting adaptation and survival in both hosts and pathogens.
Morphine plays a critical regulatory role in both simple and complex plant species. Dopamine is a critical chemical intermediate in the morphine biosynthetic pathway and may have served as a primordial agonist in developing catecholamine signaling pathways. While dopamine remains the preeminent catecholamine in invertebrate neural systems, epinephrine is the major product of catecholamine synthetic pathways in vertebrate species.
View Article and Find Full Text PDFHIV, HSV, SARS-CoV-2 and Ebola Share Long-Term Neuropsychiatric Sequelae.
Neuropsychiatr Dis Treat
October 2022
Long COVID, in which disease-related symptoms persist for months after recovery, has led to a revival of the discussion of whether neuropsychiatric long-term symptoms after viral infections indeed result from virulent activity or are purely psychological phenomena. In this review, we demonstrate that, despite showing differences in structure and targeting, many viruses have highly similar neuropsychiatric effects on the host. Herein, we compare severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human immunodeficiency virus 1 (HIV-1), Ebola virus disease (EVD), and herpes simplex virus 1 (HSV-1).
View Article and Find Full Text PDF